rare-diseases-germany-2019

Hematological Diseases

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There are many conditions affecting the human hematological system — the biological system that includes plasma, platelets, leukocytes, and erythrocytes, which the major component portions of blood and the bone marrow.  It also implies structural abnormalities in the globin proteins in rare hematlogical analysis. It also usually occurs in underproduction of normal globin proteins, often leads through mutations in regulatory genes. The two conditions may overlap, however, since some conditions which further causes of rare abnormalities in globin haematological proteins (hemoglobinopathy) also influence the production (thalassemia).Hemoglobin variants are a part of the normal embryonic and fetal development, but may also be pathologic mutant forms of hemoglobin, caused by variations in genetics diseases in rare conditions. Other variants cause no detectable pathology, and are thus considered non-pathological variants. In patients predisposed for rapid clearance of red blood cells, this may lead to early destroy of cells infected with the parasite and increasing the chance of survivasl for the carrier of the trait.