Patrick .J. Tighe
University of Nottingham
UK
Biography
Dr Paddy Tighe is Associate Professor of Immunology within the School of Life Sciences, The University of Nottingham. Dr Tighes laboratory studies dysregulated immune function and biomarkers associated with a range of chronic diseases with immune system involvement focusing on the orphan autoinflammatory syndromes, and TNF-receptor-associated periodic syndrome (TRAPS) in particular. We were first to report the ligand-independent signaling processes triggered by intracellular accumulation of mutant TNFR1 in TRAPS and our MRC –funded development of high-throughput, high-content methods for intracellular signalling analysis has provided insight into the underlying mechanisms and potential targets for novel therapeutic agents for TRAPS. Current interests are comprehensive mapping of the TRAPS-associated inflammatory phenotype for improved diagnostics and identification of novel therapeutics and associated research into drug-repurposing for TRAPS treatment.
Abstract
Abstract : Pathway-Centric analysis of rare autoinflammatory diseases (AID) and drug repurposing
